Skip to main content
U.S. flag

An official website of the United States government

Here’s how you know

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

HTTPS

Secure .gov websites use HTTPS
A lock ( Lock A locked padlock ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

  • Environmental Topics
  • Laws & Regulations
  • Report a Violation
  • About EPA
Risk Assessment
Contact Us

Age-Related Differences In Susceptibility To Carcinogenesis - A Quantitative Analysis Of Empirical Animal Bioassay Data

On this page:

  • Overview
  • Downloads
As part of its revision of cancer risk assessment guidelines, the U.S. Environmental Protection Agency has assembled and analyzed animal cancer bioassay data for exposures to mutagenic and putatively non-mutagenic chemicals over different periods of life. This paper reports an improved analysis of these data, supplemented with some chemical carcinogenesis data not included in the orginal analysis, and animal bioassay studies of ionizing radiation. We use likelihood methods to avoid excluding cases where no tumors were observed in either adult or other groups. We express dosage for animals of different weights on a metabolically consistent basis (either concentration in air or food, or per unit body weight to the three quarters power). Finally, we use a system of dummy variables to represent exposures during fetal, pre-weaning, and weaning-60 day postnatal periods -- yielding separate estimates of relative sensitivity per day of dosing in these intervals.

Impact/Purpose

journal article

Citation

Hattis, D., R. Goble, AND A. Russ. Age-Related Differences In Susceptibility To Carcinogenesis - A Quantitative Analysis Of Empirical Animal Bioassay Data. 112(11):1152-1158, (2004).

Download(s)

  • DX.DOI.ORG
  • Risk Assessment Home
  • About Risk Assessment
  • Risk Recent Additions
  • Human Health Risk Assessment
  • Ecological Risk Assessment
  • Risk Advanced Search
    • Risk Publications
  • Risk Assessment Guidance
  • Risk Tools and Databases
  • Superfund Risk Assessment
  • Where you live
Contact Us to ask a question, provide feedback, or report a problem.
Last updated on April 21, 2014
United States Environmental Protection Agency

Discover.

  • Accessibility Statement
  • Budget & Performance
  • Contracting
  • EPA www Web Snapshots
  • Grants
  • No FEAR Act Data
  • Privacy
  • Privacy and Security Notice

Connect.

  • Data
  • Inspector General
  • Jobs
  • Newsroom
  • Open Government
  • Regulations.gov
  • Subscribe
  • USA.gov
  • White House

Ask.

  • Contact EPA
  • EPA Disclaimers
  • Hotlines
  • FOIA Requests
  • Frequent Questions

Follow.