IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (External Review Draft)
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Abstract
EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of cis- and trans-1,2-dichloroethylene that will appear in the Integrated Risk Information System (IRIS) database.The draft Toxicological Review of cis- and trans-1,2-dichloroethylene provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to cis- and trans-1,2-dichloroethylene. 1,2-Dichloroethylene is used as a solvent for waxes and resins, in rubber extraction, and as a coolant in refrigeration plants. The cis- and trans- isomers have slightly different physical, chemical, and biological properties. The trans-isomer is more widely used. 1,2-Dichloroethylene is frequently detected at federal and state hazardous waste sites across the country.
Impact/Purpose
The draft Toxicological Review of cis- and trans-1,2-dichloroethylene provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to cis- and trans-1,2-dichloroethylene.Status
Following external peer review of the report, the final assessment will be posted to the IRIS database.Citation
U.S. EPA. IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/006, 2009.History/Chronology
| Date | Description |
|---|---|
| 01- Sep 1988 | EPA posted the trans-1,2-dichloroethylene assessment (RfD only). |
| 02- Dec 1990 | EPA posted the cis-1,2-dichloroethylene (qualitative cancer assessment only). |
| 03- Aug 2009 | EPA hosted an interagency science discussion on the review of the draft IRIS Summary and Toxicological Review of cis-and trans-1,2-Dichloroethylene. |
| 04- Sep 2009 | EPA released an external review draft of the assessment for public review and comment. |
| 05- Nov 2009 | EPA announces the details of an external peer review workshop to be held on December 17, 2009 in a November 10, 2009 Federal Register Notice. |
| 06- Jan 2010 | EPA releases the comments from the public comment period and external review workshop. |
Additional Information
Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select Environmental Protection Agency and the key word EPA- HQ-ORD-2009-0348 (for the docket ID).Download(s)
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- IRIS Toxicological Review of Cis-and Trans-1,2-Dichloroethylene (External Review Draft) (PDF) (150 pp, 908.2 KB, about PDF)
- Charge to External Peer Reviewers (PDF) (3 pp, 14.6 KB, about PDF)
- Consolidated Comments from the External Peer Review (Final) (PDF) (48 pp, 205.1 KB, about PDF)
Related Link(s)
- McCauley et al 1990. The effects of subacute and subchronic oral exposure to cis-1,2-dichloroethylene in rats (PDF) (44 pp, 783.2 KB, about PDF)
- IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (Final Report)
- IRIS Toxicological Review of cis- & trans-1,2-Dichloroethylene (Interagency Science Consultation Draft)
- IRIS Toxicological Review of cis- & trans-1,2-Dichloroethylene (Interagency Science Discussion Draft)