IRIS Toxicological Review of Hydrogen Cyanide and Cyanide Salts (Interagency Science Discussion Draft)

Abstract

EPA is releasing the draft report, Toxicological Review of Hydrogen Cyanide (HCN) and Cyanide Salts, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments.
The draft Toxicological Review of Hydrogen Cyanide and Cyanide Salts provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to hydrogen cyanide and cyanide salts. Cyanide compounds are used in a number of industrial processes including mining, electroplating, metallurgy, chemical manufacturing, and photography because these compounds can form stable complexes with a range of metals. Hydrogen cyanide is also a component of tobacco smoke, vehicle exhaust, and is produced by the burning of some plastics. Cyanide salts, such as potassium and sodium cyanide, are also used as rodenticides.

Impact/Purpose

The draft Toxicological Review of Hydrogen Cyanide and Cyanide Salts provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to hydrogen cyanide and cyanide salts.

Status

Now that the interagency review draft has been completed and finalized, this assessment has been loaded into the IRIS Web site and Database.

Citation

U.S. EPA. IRIS Toxicological Review of Hydrogen Cyanide and Cyanide Salts (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-08/016D, 2010.

Date	Description
01- Jan 1987	EPA posted an assessment for cyanide salts (RfD only).
02- Sep 1994	EPA posted an assessment for hydrogen cyanide (RfC only).
03- Jun 2004	The draft IRIS reassessment of hydrogen cyanide was started.
04- Sep 2009	EPA released an external review draft of the assessment for public review and comment.
05- Oct 2009	EPA announced a public listening session to be held on October 27, 2009. [Federal Register Notice Sep 23, 2009]
06- Nov 2009	EPA announced an external peer review workshop to be held on December 14, 2009. [Federal Register Notice Nov 10, 2009]
07- Jan 2010	EPA released the comments from the public comment period and external review workshop.
08- Aug 2010	EPA hosted an interagency science discussion on the review of the draft document.
09- Sep 2010	EPA released the final toxicological report and IRIS Summary for Hydrogen Cyanide and the interagency review draft with comments.

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

• Toxicological Review of Hydrogen Cyanide and Cyanide Salts (Interagency Science Discussion Draft) (PDF)  (149  pp, 948.2 KB, about PDF)
• Hydrogen Cyanide and Cyanide Salts Summary (Interagency Science Discussion Draft) (PDF)  (21  pp, 128.9 KB, about PDF)
• 1. HCN ATSDR IASD Comments (PDF)  (1  pp, 40.0 KB, about PDF)
• 2. HCN FDA IASD Comments (PDF)  (4  pp, 1.9 MB, about PDF)
• 3. HCN FDA IASD Comments - Addendum (PDF)  (3  pp, 25.4 KB, about PDF)
• 4. HCN NIEHS IASD Comments (PDF)  (1  pp, 20.5 KB, about PDF)
• 5. HCN OMB IASD Comments (PDF)  (4  pp, 29.3 KB, about PDF)

Related Link(s)

• IRIS Toxicological Review of Hydrogen Cyanide (External Review Draft)
• IRIS Toxicological Review of Hydrogen Cyanide and Cyanide Salts (Final Report)