2009 Status Report: Advances In Inhalation Dosimetry of Gases and Vapors With Portal of Entry Effects In the Upper Respiratory Tract

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The U.S. EPA has released the final status report entitled Advances in Inhalation Dosimetry of Gases and Vapors with Portal of Entry Effects in the Upper Respiratory Tract.

Abstract

This status report provides a review of the advances in the state of the science for interspecies inhalation gas dosimetry related to the upper respiratory tract (URT) or nasal tract region.
This report reviews advances in the state of the science for inhalation gas dosimetry related to the URT or nasal tract region that have occurred since the publication of the Methods for Derivation of Inhalation Reference Concentrations and Application of Inhalation Dosimetry; EPA/600/8-90/066F, October 1994 (RfC Methods). The RfC Methods document provides the basis for EPA extrapolation of data from animal toxicology studies to estimate delivered dose in humans as part of the development of inhalation reference values (i.e., RfC values).The primary results from this review include empirical information related to the assumptions underlying the current methodology used by EPA, as well as how the state of the science and advanced dosimetry modeling techniques inform these assumptions. The intent of this report is to serve as a source document for revisions to the Agency’s RfC Methods. The report makes clear that it is intended neither to displace the current procedures for gas dosimetry in RfC Methods nor to reflect on use of these procedures in assessments currently in IRIS.

Impact/Purpose

The purpose of this report is to briefly review advances in the state-of-the-science for inhalation gas dosimetry related to the upper respiratory tract (URT) or nasal tract region.

Status

This is the final report.

Citation

U.S. EPA. 2009 Status Report: Advances In Inhalation Dosimetry of Gases and Vapors With Portal of Entry Effects In the Upper Respiratory Tract. U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-09/072, 2009.

History/Chronology

Date	Description
01- Jun 2009	Internal EPA workgroup review and management review.
02- Jul 2009	Revised report submitted to independent, external peer review.
03- Aug 2009	Revised final report based on peer review comments.
04- Sep 2009	EPA released the final report.

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This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.

Status Report: Advances in Inhalation Dosimetry of Gases and Vapors with Portal of Entry Effects in the Upper Respiratory Tract (PDF) (100 pp, 876.0 KB, about PDF)