CHROMATIN REMODELING IN MAMMALIAN ZYGOTES

Abstract

With sperm-egg fusion at the time of fertilization the gamete nuclei are remodeled from, genetically quiescent structures into pronuclei capable of DNA synthesis. Features of this process that are critical to insure the genetic integrity of the ZygOtE and the success of subsequent embryonic development include: oocyte responses that prevent polyspermy; completion of the 2nd meiotic division by the oocyte; exchange of proteins in th(- @perm nucleus; and, remodelling of the oocyte chromosomes and sperm nucleus into functional pronuclei. Elucidation of the biological and molecular mechanisms underlying zygote formation and chromatin remodeling should enhance our understanding of the potential vulnerability of the zygote to toxicant-induced damage.

Citation

Perreault, S. CHROMATIN REMODELING IN MAMMALIAN ZYGOTES. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-93/173.

Additional Information

Mutation Research 296(1/2):43-55, 1992

• CHROMATIN REMODELING IN MAMMALIAN ZYGOTES