REGULATORY HISTORY AND EXPERIMENTAL SUPPORT OF UNCERTAINTY (SAFETY) FACTORS

On this page:

Overview
History
Downloads

Alert
Notice - This site contains archived material(s)

Archive disclaimer
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the Risk Webmaster for assistance. Please use the contact us form if you need additional support.

Abstract

A synthesis of available literature on uncertainty (safety) factors which are used to estimate acceptable daily intakes (ADIs) for toxicants is presented. The synthesis reveals reasonable qualitative biological premises, as well as specific biological data that support both the use and choice of these factors. A suggestion is made in order to derive a range of ADI. Research needs in various areas of uncertainty are also identified.

Citation

Dourson, M. AND J. Stara. REGULATORY HISTORY AND EXPERIMENTAL SUPPORT OF UNCERTAINTY (SAFETY) FACTORS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-83/315 (NTIS PB86100310).

History/Chronology

Additional Information

Pub. in Regulatory Toxicology and Pharmacology 3, p224-238 1983.

Download(s)

REGULATORY HISTORY AND EXPERIMENTAL SUPPORT OF UNCERTAINTY (SAFETY)FACTORS