Development of a data set on tumours and tumour sites in humans and in experimental animals for Group-1 agents identified through Volume 109 of the IARC Monographs.

This chapter/appendix describes the construction of a database of tumor sites identified for more than 100 carcinogenic agents. The database was used in the chapter on tumor-site concordance and is a resource available to the cancer research community.

Impact/Purpose

The International Agency for Research on Cancer recently completed an update and review of the more than 100 agents classified as carcinogenic to humans by the IARC Monographs programme since 1970. They used this new information to answer two questions that are important to the risk assessment of carcinogens: cancer-site concordance between humans and experimental animals, and the identification of mechanistic events that are either established or likely to occur during the development of cancer in humans. IARC is published these analyses as an IARC Scientific Publication on Tumour-Site Concordance and Mechanisms of Carcinogenesis.

Citation

Grosse, Y., P. Lajoie, M. Billard, D. Krewski, J. Rice, V. Cogliano, M. Bird, AND J. Zielinski. Development of a data set on tumours and tumour sites in humans and in experimental animals for Group-1 agents identified through Volume 109 of the IARC Monographs. R.A. Baan, B.W. Steward, and K. Straif Tumour Site Concordance and Mechanisms of Carcinogenesis; IARC Scientific Publication No. 165.. International Agency for Research on Cancer, Lyon, FRANCE, 165:283-289, (2019).

• https://www.ncbi.nlm.nih.gov/books/NBK570345/