IRIS Toxicological Review of Hexavalent Chromium (Peer Review Draft)
EPA is planning to released the IRIS Toxicological Review of Hexavalent Chromium (External Review Draft). As part of developing a draft IRIS assessment, EPA presents a methods document, referred to as the protocol, for conducting a chemical-specific systematic review of the available scientific literature. Protocols include strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.
This protocol includes strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.
This protocol includes strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.
Impact/Purpose
EPA is undertaking development of the Integrated Risk Information System (IRIS) health assessment for Hexavalent Chromium. The outcome of this project is an IRIS Toxicological Review and Executive Summary for Hexavalent Chromium will be entered into the IRIS database.Citation
U.S. EPA. IRIS Toxicological Review of Hexavalent Chromium (Peer Review Draft). U.S. Environmental Protection Agency, Washington, DC.History/Chronology
Date | Description |
---|---|
05- Mar 2019 | EPA released the Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials). [Federal Register Notice Mar 15, 2019] |
07- Oct 2022 | EPA released the external review draft report for a 60-day public comment period with a subsequent external peer review by EPA’s Science Advisory Board (SAB). |
Download(s)
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- IRIS TOXICOLOGICAL REVIEW OF HEXAVALENT CHROMIUM [CR(VI)] (PDF) (PDF) (507 pp, 6.7 MB, about PDF)
- IRIS TOXICOLOGICAL REVIEW OF HEXAVALENT CHROMIUM [CR(VI)] SUPPLEMENTAL INFORMATION (PDF) (PDF) (433 pp, 13.4 MB, about PDF)
- Agenct Charge to Reviewers (PDF) (8 pp, 236.3 KB, about PDF)
- REVIEW OF EPA’S DRAFT IRIS TOXICOLOGICAL REVIEW OF HEXAVALENT CHROMIUM (PDF) (146 pp, 2.6 MB, about PDF)