Cumulative assessment approaches: Laboratory research informing multiple chemical exposures
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Due to the pervasive detection of multiple compounds such as PFAS and phthalates in human and environmental matrices, many health-based agencies are employing or pursuing cumulative assessment and regulatory approaches. We have conducted many phthalate mixture studies and some of the only in vivo PFAS mixture studies investigating maternal and neonatal effects from maternal exposure during pregnancy in a rat model. Experimental data were compared to predictions using established mixtures toxicology approaches and effects were well predicted using dose addition methods. This presentation broadly discusses mixtures research and highlights the two most recent mixtures publications from our research group.