Incorporating neuroendocrine mechanisms and resiliency in assessing air pollution health effects
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Considering neuroendocrine stress response in PM studies. Neuroendocrine stress response is an acute reaction to exposure/less stress - which we generally referred as toxicity - for inhaled pollutants producing respiratory, neural and peripheral effects, likely inseparable from chronic response. Neuroendocrine response to reactive air pollutant exposure is dynamic and regulated by adrenal-derived stress hormones. This response is plastic, thus linked to adaptation/habituation/ resiliency and involves adrenal-derived glucocorticoids – allostatic load.