ORD Human Health Toxicity Value for Perfluoropropanoic Acid (CASRN 422-64-0 | DTXSID8059970)
Perfluoropropanoic Acid (PFPrA; CASRN 422-64-0) and its related salts are members of the group of per and polyfluoroalkyl substances (PFAS). This toxicity assessment is a written summary of the potential health effects associated with exposure to PFPrA (hazard identification) and identifies the exposure levels (dose-response assessment) at which those health effects may occur. The ORD toxicity assessment focuses on chemical hazard identification and dose-response analyses that can be used along with oral exposure information and other risk management considerations to assess potential risks of PFPrA to human health. As part of ORD’s toxicity assessment, the Agency has developed an oral reference dose (RfD) for PFPrA. No known studies have evaluated potential cancer effects of PFPrA. The focus of the assessment was on noncancer, so no cancer determination was included.
Impact/Purpose
EPA’s HERA program has posted the final Office of Research and Development (ORD) Human Health Toxicity Value for Perfluoropropanoic Acid (PFPrA) assessment. This toxicity assessment provides actionable science to inform EPA decision contexts and was developed in response to a request for site-specific technical support.Citation
U.S. EPA. ORD Human Health Toxicity Value for Perfluoropropanoic Acid (CASRN 422-64-0 | DTXSID8059970). U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-22-042F, 2023.Download(s)
This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.