Evaluating Impacts of Physiological Variability on Human Equivalent Doses Using PBPK Models - SEARCDE 2022 Presentation

This Sub-Product includes materials (an abstract and presentation slides or poster) for a presentation for the Southeastern-Atlantic Regional Conference on Differential Equations (SEARCDE) which will occur 11/12/2022 through 11/13/2022. The presentation will describe methods and results related to HERA.403.3.2 (Determining and evaluating distributions for dose metrics and equivalent doses via parameter sampling and pharmacokinetic (PK) modeling).

Impact/Purpose

This Sub-Product includes materials (an abstract and presentation slides or poster) for a presentation for the Southeastern-Atlantic Regional Conference on Differential Equations (SEARCDE) which will occur 11/12/2022 through 11/13/2022. The authors investigated how the shapes of human equivalent dose (HED) distributions were impacted when they made different assumptions about the distributions of model parameters in physiologically based pharmacokinetic (PBPK) models for dichloromethane and chloroform. Using the Royston normality test, they found that while some HED distributions were lognormal, this depended on the distributions chosen to represent parameter variability as well as the applied doses.

Citation

Schacht, C., A. Meade, A. Bernstein, B. Prasad, P. Schlosser, H. Tran, AND D. Kapraun. Evaluating Impacts of Physiological Variability on Human Equivalent Doses Using PBPK Models - SEARCDE 2022 Presentation. Southeastern-Atlantic Regional Conference on Differential Equations, Raleigh, NC, November 12 - 13, 2022.