Body Weight Data
Perfluorononanoate (PFNA) is one of the legacy perfluoroalkyl substances (PFAS) identified by US EPA for development of human health toxicity assessment (including Systematic Review for IRIS Assessment) that is currently underway. In the past decade, research was undertaken by ORD investigators to characterize the toxicity of PFNA with mouse and rat models. Our findings have been published previously in peer-reviewed journals that included species comparison of pharmacokinetic profiles of PFNA (Tatum-Gibbs et al., 2011, Toxicology 281:48); developmental toxicity of PFNA in the mouse (Das et al., 2015, Reprod. Toxicol. 51:133); involvement of peroxisome proliferation activated receptor-alpha in developmental toxicity of PFNA (Wolf et al., 2010, PPAR Research Article ID 282896); and presser effects of PFNA in rat offspring after maternal exposure (Rogers et al., 2014, Tox. Sci. 137:436). Data from the last three papers on body weight gains of the rodent offspring after prenatal exposure to PFNA were chosen by the IRIS managers as one of the endpoints for point-of-departure derivation. To support this exercise, raw pup weight data from these studies are compiled (in excel files) by the respective authors and submitted to Science Hub for public dissemination.
Impact/Purpose
To support risk assessment of Perfluorononanoate (PFNA) in IRIS program.Citation
Lau, C., K. Das, AND C. Wolf. Body Weight Data. U.S. Environmental Protection Agency, Washington, DC, 2024. [DOI: 10.23719/1529407]Download(s)
DOI:
Body Weight Data