Estimating epigenetic age acceleration’s causal effect on cardiovascular and inflammatory responses to ozone exposure: a block randomization approach Causal evaluation of the modification of associations between ozone exposure and cardiovascular and inflammatory outcomes by epigenetic age acceleration

presentation  ISEE North America Chapter Meeting Median regression results provided evidence that epigenetic age acceleration increases ozone exposure’s causal risk for a prolonged QTc interval and an  attenuated CRP level •Fisher-exact results agreed with asymptotic results •The block group model provided evidence that ozone exposure increases the causal risk for a prolonged QTc interval, an attenuated CRP level, and an attenuated PAI1 level, when subjects display elevated epigenetic age acceleration •For QTc and CRP: the block group results paralleled our median regression •Conclusion – accelerated epigenetic age could modify cardiovascular, inflammatory, and hemostatic responses to ozone exposure. Future work should evaluate the molecular relationship between ozone’s effect on QTc, CRP and PAI1, in relation to epigenetic age acceleration.

Impact/Purpose

presentation to the ISEE 2023 North America Chapter Meeting  Median regression results provided evidence that epigenetic age acceleration increases ozone exposure’s causal risk for a prolonged QTc interval and an  attenuated CRP level

Citation

Weston, William Chris, M. Bind, D. Diaz-Sanchez, W. Cascio, R. Devlin, AND C. Ward-Caviness. Estimating epigenetic age acceleration’s causal effect on cardiovascular and inflammatory responses to ozone exposure: a block randomization approach Causal evaluation of the modification of associations between ozone exposure and cardiovascular and inflammatory outcomes by epigenetic age acceleration. ISEE North America Chapter Meeting, Corvallis, OR, June 19 - 21, 2023.