RISK ASSESSMENT OF COMPLEX MIXTURES

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Abstract

Quantitative carcinogenic assessment of complex mixtures is complicated by the variability of the mixtures. Different samples of effluents from the same source may vary in their carcinogenic potency. A multiplicative effect could be produced by the action of different fractions of a mixture on different stages of the carcinogenic process. A mathematical formula explaining this multiplicative effect is presented here. Antagonism may result from the action of different fractions on the same stage. Actual data from both epidemiologic studies and animal investigations are used for illustration.

Citation

Gibb, H. AND C. Chen. RISK ASSESSMENT OF COMPLEX MIXTURES. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/D-84/186 (NTIS PB84223478).

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