Guidelines for Mutagenicity Risk Assessment and Some Comments on Aneuploidy

Abstract

The paper describes the risk assessment strategy used by the U.S. Environmental Protection Agency (EPA) to evaluate mutagenic risk. The Agency considers all endpoints relevant to genetic risk. Evaluating and quantifying risk is not a straightforward process and requires many assumptions. The U.S. EPA mutagenicity guidelines should not be regarded as comprehensive or complete, but rather providing a reasonable guide for using toxicological data in assessing genetic risk. Because of the dynamic nature of the area, as new information is gained, the 'Guidelines' will be updated and modified if necessary.

Citation

Dellarco, V. AND D. Jacobson-Kram. Guidelines for Mutagenicity Risk Assessment and Some Comments on Aneuploidy . U.S. Environmental Protection Agency, Washington, D.C., EPA/600/D-87/312 (NTIS PB88113642), 1987.

• U.S. ENVIRONMENTAL PROTECTION AGENCY'S GUIDELINES FOR MUTAGENICITY RISK ASSESSMENT AND SOME COMMENTS ON ANEUPLOIDY