INCORPORATING CELL PROLIFERATION IN QUANTITATIVE CANCER RISK ASSESSMENT: APPROACHES, ISSUES, AND UNCERTAINTIES

Abstract

A two-stage tumor growth model that explicitly incorporates mitoticrate of initiated cells is developed. s an example, the model isapplied to data from dinitrotoluene (DNT) studies to demonstratehow information on preneoplastic and neoplastic lesions can beincorporated into the dose-response model, to critically examineits implication for (quantitative risk assessment, and to simulateissues, problems, and data gaps that may arise when one attempts toincorporate cell proliferation into the quantitative riskestimation.

Citation

Chen, C. AND W. Farland. INCORPORATING CELL PROLIFERATION IN QUANTITATIVE CANCER RISK ASSESSMENT: APPROACHES, ISSUES, AND UNCERTAINTIES. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/D-90/148 (NTIS PB90263146), 1990.

Additional Information

Presented at Symposium - Chemically Induced Cell Proliferation:Implications for Risk Assessment, November 29-December 2, 1989,Austin, Texas

• INCORPORATING CELL PROLIFERATION IN QUANTITATIVE CANCER RISKASSESSMENT: APPROACHES, ISSUES, AND UNCERTAINTIES