Inhalation New Approach Methods (NAMs) to Evaluate Environmental Health Risks

New Approach Methods (NAMs) are under development for inhalation 1.Airway Cell Models: Air-liquid interface (ALI) cell cultures available for the nasal, tracheobronchial, and alveolar regions of the human respiratory tract 2.Unique Exposures: ALI exposures preserve physicochemical properties of inhaled substances but require extensive characterization 3.Specialized Endpoints: Current NAM endpoints are tailored to acute portal-of-entry toxicity, additional studies may be required for chronic, systemic health effects slide presentation

Impact/Purpose

Invited presentation for Department of Energy (DOE) Workshop: Environmental and Health Risk Assessments of Non-CO2 Emissions. Sharing ORD's perspective on applying NAMs to assess nitrosamines and other emissions from carbon capture technology. 

Citation

Murray, J. AND M. Higuchi. Inhalation New Approach Methods (NAMs) to Evaluate Environmental Health Risks. DOE Workshop: Environmental and Health Risk Assessments of Non-CO2 Emissions, Virtual, NC, November 21, 2024.