Inhalation New Approach Methods (NAMs) to Evaluate Environmental Health Risks
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New Approach Methods (NAMs) are under development for inhalation
1.Airway Cell Models: Air-liquid interface (ALI) cell cultures available for the nasal, tracheobronchial, and alveolar regions of the human respiratory tract
2.Unique Exposures: ALI exposures preserve physicochemical properties of inhaled substances but require extensive characterization
3.Specialized Endpoints: Current NAM endpoints are tailored to acute portal-of-entry toxicity, additional studies may be required for chronic, systemic health effects
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