NC BREATHE Conference - Maternal and offspring effects of exposure to PFAS and PFAS mixtures during pregnancy

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Overview

North Carolina is a hotspot for PFAS contamination with chemical monitoring studies reporting detection of multiple emerging/next-generation PFAS in human and/or environmental samples. Further, detection of multiple PFAS in human and environmental matrices is pervasive, leading many health-based agencies to employ or pursue cumulative assessment and regulatory approaches. However, the literature is lacking mammalian in vivo studies reporting dose-response data for emerging compounds and studies that test additivity by comparing observed mixture responses to mixture model predictions. We have conducted dose-response studies with several emerging PFAS in NC that are data-deficient, as well as three different PFAS mixture studies investigating maternal and neonatal effects from maternal exposure during pregnancy in a rat model. This presentation is for a one day symposium focused on PFAS as part of the NC BREATHE Conference and is intended as a brief overview of our work for a broad audience.

Impact/Purpose

This is a slide deck for an invited presentation in the NC BREATHE Conference in a symposium titled Environmental PFAS and Human Health in 2024 held at Duke University on October 1, 2024. The studies described here are some of the only mammalian in vivo toxicity studies of these emerging PFAS. Further the mixture studies are the only mammalian toxicity studies that directly evaluate the nature of PFAS mixture responses. The results provide highly-valuable dose response data for conducting human health risk assessment of emerging PFAS. Further, the mixture studies directly support the cumulative approaches by the Office of Water in the PFAS NPDWR, as well as state and international health-based agencies that have adopted mixture-based risk assessment and regulatory approaches for exposure to multiple PFAS.

Citation

Conley, J. NC BREATHE Conference - Maternal and offspring effects of exposure to PFAS and PFAS mixtures during pregnancy. NC BREATHE Conference, Durham, NC, October 01 - 02, 2024.