NC BREATHE Conference - Maternal and offspring effects of exposure to PFAS and PFAS mixtures during pregnancy
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North Carolina is a hotspot for PFAS contamination with chemical monitoring studies reporting detection of multiple emerging/next-generation PFAS in human and/or environmental samples. Further, detection of multiple PFAS in human and environmental matrices is pervasive, leading many health-based agencies to employ or pursue cumulative assessment and regulatory approaches. However, the literature is lacking mammalian in vivo studies reporting dose-response data for emerging compounds and studies that test additivity by comparing observed mixture responses to mixture model predictions. We have conducted dose-response studies with several emerging PFAS in NC that are data-deficient, as well as three different PFAS mixture studies investigating maternal and neonatal effects from maternal exposure during pregnancy in a rat model. This presentation is for a one day symposium focused on PFAS as part of the NC BREATHE Conference and is intended as a brief overview of our work for a broad audience.