Skip to main content
U.S. flag

An official website of the United States government

Here’s how you know

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

HTTPS

Secure .gov websites use HTTPS
A lock ( Lock A locked padlock ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

  • Environmental Topics
  • Laws & Regulations
  • Report a Violation
  • About EPA
Risk Assessment
Contact Us

Epidemiological Work on Disinfection by-Product (DBP) Exposures

On this page:

  • About the Website
  • Downloads
This effort was based on several completed or existing projects where disinfection by-products ( or DBPs) have been the primary exposure of interest. Previous epidemiologic results on reproductive or developmental risks that may be associated with consumption of disinfected drinking water are considered equivocal for many reasons. Some of the between-study differences may be due to unmeasured differences in the type and occurrence levels of mixtures of DBPs and other water exposures. These differences may also be due to incomplete assessment of all likely routes of exposure to humans and reliance on aggregate measures to estimate individual-level exposures. The integration of individual-level data will decrease these exposure uncertainties, aid decision makers in interpreting the results of both epidemiologic and toxicologic studies of waterborne chemical exposures, and will also further develop the scientific approaches for aggregate exposure assessment.

Exposure assessment limitations in environmental epidemiology is a major scientific issue with implications for public health policy. This project will integrate individual-level questionnaire-based information from epidemiologic study settings for different routes of exposure to DBPs. Data on the within- and between-individual variability in water consumption and water-related activities will be used to develop maternal exposure metrics. A sensitivity analysis evaluating the amount of exposure misclassification due to the use of different exposure metrics will be conducted. These exposure metrics may also be used in the parent study to examine their impact on risk for adverse reproductive outcomes in humans.

Download(s)

  • A SENSITIVITY ANALYSIS OF BIAS IN RELATIVE RISK ESTIMATES DUE TO DISINFECTION BY-PRODUCT EXPOSURE MISCLASSIFICATION (PDF)  (5  pp, 117.2 KB, about PDF)
  • The impact of water consumption, point-of-use filtration and exposure categorization on exposure misclassification of ingested drinking water contaminants (PDF)  (65  pp, 127.0 KB, about PDF)
  • Predictors of use and consumption of public drinking water among pregnant women (PDF)  (11  pp, 154.3 KB, about PDF)
  • The effect of boiling water on disinfection by-product exposure (PDF)  (10  pp, 252.0 KB, about PDF)

Related Link(s)

  • PROJECT OVERVIEW: INDIVIDUAL LEVEL VARIABILITY IN WATER USE PATTERNS AMONG PREGNANT WOMEN
  • Risk Assessment Home
  • About Risk Assessment
  • Risk Recent Additions
  • Human Health Risk Assessment
  • Ecological Risk Assessment
  • Risk Advanced Search
    • Risk Publications
  • Risk Assessment Guidance
  • Risk Tools and Databases
  • Superfund Risk Assessment
  • Where you live
Contact Us to ask a question, provide feedback, or report a problem.
Last updated on May 20, 2019
United States Environmental Protection Agency

Discover.

  • Accessibility Statement
  • Budget & Performance
  • Contracting
  • EPA www Web Snapshots
  • Grants
  • No FEAR Act Data
  • Privacy
  • Privacy and Security Notice

Connect.

  • Data
  • Inspector General
  • Jobs
  • Newsroom
  • Open Government
  • Regulations.gov
  • Subscribe
  • USA.gov
  • White House

Ask.

  • Contact EPA
  • EPA Disclaimers
  • Hotlines
  • FOIA Requests
  • Frequent Questions

Follow.