IRIS Toxicological Review of 1,1,2,2-Tetrachloroethane (Interagency Science Discussion Draft)
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Abstract
EPA is releasing the draft report, Toxicological Review of 1,1,2,2-Tetrachloroethane, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments.The draft Toxicological Review of 1,1,2,2-Tetrachloroethane provides scientific support and rationale for the hazard and dose-response assessment pertaining to subchronic and chronic exposure to 1,1,2,2-tetrachloroethane. 1,1,2,2-Tetrachloroethane (1,1,2,2TCE; CASRN 79-34-5) is a synthetic halogenated hydrocarbon that is a colorless, nonflammable liquid at room temperature. The major use for 1,1,2,2-Tetrachloroethane was in the production of trichloroethylene, tetrachloroethylene, and 1,2-Dichloroethylene.
Impact/Purpose
The draft Toxicological Review of 1,1,2,2-Tetrachloroethane provides scientific support and rationale for the hazard and dose-response assessment pertaining to subchronic and chronic exposure to 1,1,2,2-Tetrachloroethane.Status
Now that the interagency review draft has been completed and finalized, this assessment has been loaded into the IRIS Web site and Database.Citation
U.S. EPA. IRIS Toxicological Review of 1,1,2,2-Tetrachloroethane (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/001D, 2010.History/Chronology
| Date | Description |
|---|---|
| 01- Mar 1987 | EPA posted a 1,1,2,2-Tetrachloroethane carcinogenicity assessment. |
| 03- Sep 2009 | EPA released an external review draft of the assessment for public review and comment. |
| 04- Dec 2009 | EPA announced an external peer review workshop to be held on January 27, 2010 in a December 17, 2009 Federal Register Notice. |
| 05- Feb 2010 | EPA released the comments from the external review workshop and the public comment period. |
| 06- Aug 2010 | EPA hosted an interagency science discussion on the review of the draft Toxicological Review of 1,1,2,2-tetrachloroethane. |
| 07- Sep 2010 | EPA released the final report and the interagency science discussion draft with comments. |
Download(s)
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- Toxicological Review of 1,1,2,2-Tetrachloroethane (Interagency Science Discussion Draft) (PDF) (214 pp, 1.5 MB, about PDF)
- 1,1,2,2-Tetrachloroethane Summary (Interagency Science Discussion Draft) (PDF) (21 pp, 136.7 KB, about PDF)
- tetrachloroethane ATSDR IASD Comments (PDF) (1 pp, 46.9 KB, about PDF)
- tetrachloroethane CEQ IASD Comments (PDF) (1 pp, 39.1 KB, about PDF)
- tetrachloroethane NIEHS IASD Comments (PDF) (1 pp, 36.1 KB, about PDF)
- tetrachloroethane OMB IASD Comments (PDF) (3 pp, 25.4 KB, about PDF)