IRIS Toxicological Review of Urea (External Review Draft)
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Abstract
EPA conducted a peer review and public comment of the scientific basis of a draft report supporting the human health hazard and dose-response assessment of Urea that when finalized will appear on the Integrated Risk Information System (IRIS) database.The draft Toxicological Review of Urea provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to Urea. Urea, also known as carbamide, is an endogenous product of protein and amino acid catabolism. It can also be produced synthetically by combining ammonia, carbon monoxide, and sulfur in methanol. Urea is utilized in diesel selective catalyst reduction, in fertilizers and animal feed, plastics, flame-proofing agents, adhesives, flavoring agents and consumer goods such as liquid soaps, detergents and household cleaning products.
Impact/Purpose
The draft Toxicological Review of Urea provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to Urea.Status
Following external peer review and public comment, the final assessment will be posted to the IRIS database.Citation
U.S. EPA. IRIS Toxicological Review of Urea (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-10/005A, 2010.History/Chronology
| Date | Description |
|---|---|
| 02- Jun 2010 | EPA initiated the interagency science consultation on the draft Toxicological Review of Urea. |
| 03- Sep 2010 | EPA released the External Review Draft for public review and comment and the interagency science consultation review draft with comments. [Federal Register Sep 28, 2010] |
| 04- Nov 2010 | EPA announced the external peer review meeting to be held on December 13, 2010 via teleconference. [Federal Register Nov 10, 2010] |
| 05- Jan 2011 | EPA releases the comments from the public comment period and external review workshop. |
Additional Information
Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select “Environmental Protection Agency” and the keyword “EPA-HQ-ORD-2010-0633" (for the docket ID) to comment on this report.Download(s)
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- Toxicological Review of Urea : in Support of Summary Information on the Integrated Risk Information System (IRIS) (PDF) (94 pp, 533.2 KB, about PDF)
- Charge to the External Reviewers (PDF) (2 pp, 14.6 KB, about PDF)
- Consolidated Comments from the External Peer Review (Final) (PDF) (30 pp, 155.3 KB, about PDF)