Meeting Materials for the 4th NRC Meeting on the Guidance for and the Review of EPA's Toxicological Assessment of Inorganic Arsenic

On December 2-3, 2015, the National Research Council (NRC) hosted the 4th meeting of the committee formed to peer review the draft IRIS assessment of inorganic arsenic. EPA presented background and overview materials during the public session on December 2nd. This information covered the systematic review methods, approaches for mode of action analyses and hazard identification, toxicokinetics, and approaches for dose-response that are under development in the assessment.

Impact/Purpose

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• Introduction to the IRIS Toxicological Review of Inorganic Arsenic (PDF)  (14  pp, 965.8 KB, about PDF)
• Approach to Systematic Review for the IRIS Toxicological Review of Inorganic Arsenic (PDF)  (25  pp, 760.7 KB, about PDF)
• Hazard Identification for the IRIS Toxicological Review of Inorganic Arsenic (PDF)  (19  pp, 685.5 KB, about PDF)
• Conceptual Mechanistic Models for the IRIS Toxicological Review of Inorganic Arsenic (PDF)  (21  pp, 1.4 MB, about PDF)
• Toxicokinetics for the IRIS Toxicological Review of Inorganic Arsenic (PDF)  (16  pp, 667.0 KB, about PDF)
• Dose-Response Methods for the IRIS Toxicological Review of Inorganic Arsenic (PDF)  (29  pp, 981.4 KB, about PDF)
• Assessment Development Plan for the Integrated Risk Information System (IRIS) Toxicological Review of Inorganic Arsenic (PDF)  (32  pp, 769.5 KB, about PDF)