IRIS Toxicological Review of Trichloroacetic Acid (TCA) (Interagency Science Discussion Draft)
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Abstract
EPA is releasing the draft report, Toxicological Review of Trichloroacetic Acid (TCA), that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments.The draft Toxicological Review of Trichloroacetic Acid provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to chronic exposure to trichloroacetic acid. Trichloroacetic acid is used as an antiseptic, skin peeling agent, and chemical intermediate to produce a variety of organic chemicals. Trichloroacetic acid is also used industrially as an etching and pickling agent for surface treatment of metals and as a solvent in the plastics industry. Trichloroacetic acid is formed from organic materials during water chlorination.
Impact/Purpose
The draft Toxicological Review of Trichloroacetic Acid provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to chronic exposure to trichloroacetic acid.Status
This assessment has been loaded into the IRIS Web site and Database.Citation
U.S. EPA. IRIS Toxicological Review of Trichloroacetic Acid (TCA) (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/003D, 2011.History/Chronology
| Date | Description |
|---|---|
| 03- Aug 2009 | EPA hosted an interagency science consultation on the draft Toxicological Review of Trichloroacetic Acid. |
| 04- Sep 2009 | EPA released an External Reviewer Draft for public comment. EPA also announced a public listening session on Nov 4, 2009 [Federal Register Sep 24, 2009] |
| 05- Nov 2009 | EPA announced the external peer review meeting to be held on December 10, 2009. [Federal Register Nov 10, 2009] |
| 06- Jan 2010 | EPA released the comments from the external review workshop. |
| 07- Jul 2011 | EPA hosted an interagency science discussion on the review of the draft Toxicological Review of Trichloroacetic Acid. |
| 08- Sep 2011 | EPA releases the final toxicological review and IRIS Summary for Trichloroacetic Acid and the interagency science discussion draft with interagency comments. |
Download(s)
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- IRIS Toxicological Review of Trichloroacetic Acid (Interagency Science Discussion Draft) (PDF) (275 pp, 1.6 MB, about PDF)
- Trichloroacetic Acid Summary (Interagency Science Discussion Draft) (PDF) (20 pp, 139.6 KB, about PDF)
- EPA's Response & Interagency Science Discussion Comments (PDF) (11 pp, 117.2 KB, about PDF)
- 1. NIEHS NTP TCA IASD Comments (PDF) (1 pp, 53.7 KB, about PDF)
- 2. OMB TCA IASD comments (PDF) (4 pp, 43.9 KB, about PDF)