IRIS Toxicological Review of Tetrachloroethylene (Perchloroethylene) (Interagency Science Discussion Draft)

Abstract

EPA is releasing the draft report, Toxicological Review of Tetrachloroethylene (Perchloroethylene), that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments.
Tetrachloroethylene (perc) is a chemical solvent widely used in dry cleaning, metal degreasing, the manufacture of some consumer products and other chemicals. It is a prevalent groundwater and drinking water contaminant, is present in hundreds of Superfund sites, and has been detected in the air in and around dry cleaning facilities and nearby residences.

Impact/Purpose

Tetrachloroethylene is a chemical solvent that is widely used for dry cleaning of fabrics, metal degreasing, and in making some consumer products and other chemicals.

Status

This assessment has been loaded into the IRIS Web site and Database.

Citation

U.S. EPA. IRIS Toxicological Review of Tetrachloroethylene (Perchloroethylene) (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-08/011D, 2011.

Date	Description
05- Jul 2008	EPA released the external review draft of the IRIS Toxicological Review of Tetrachloroethylene (Perchloroethylene) for public review and comment.
07- Aug 2008	EPA hosted a public listening session as announced in the July 29, 2008 Federal Register Notice.
08- Nov 2008	National Academy of Sciences (NAS) conducted an external peer review meeting to review the draft document on Nov. 13-14, 2008 in Washington DC as announced in the October 16, 2008 Federal Register Notice
09- Jan 2009	NAS held their second external review meeting to discuss the draft peer review report on Jan 29-30, 2009, in Washington DC.
11- Apr 2009	NAS announced a third external review meeting to discuss the draft peer review report on Apr 2-3, 2009, in Irvine, CA.
12- Feb 2010	The National Research Council releases the Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene. [NAS Press Release February 9, 2010]
13- Aug 2011	EPA hosted an interagency science discussion on the review of the draft Toxicological Review and draft IRIS Summary for Tetrachloroethylene (Perchloroethylene).
14- Oct 2011	EPA hosted a second interagency science discussion as follow-up to the August discussion.
15- Feb 2012	EPA released the final IRIS Toxicological Review and IRIS Summary for Tetrachloroethylene (Perchloroethylene), and the Interagency review draft, the interagency review comments, and EPA's response to major interagency comments.

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

• IRIS Toxicological Review of Tetrachloroethylene (Interagency Science Discussion Draft) (PDF)  (750  pp, 6.4 MB, about PDF)
• IRIS Toxicological Review of Tetrachloroethylene (Interagency Science Discussion Draft) (Appendices Only) (PDF)  (293  pp, 2.0 MB, about PDF)
• IRIS Summary for Tetrachloroethylene (Interagency Science Discussion Draft) (PDF)  (28  pp, 276.4 KB, about PDF)
• External Peer Review of the Application on Physiologically-Based Pharmacokinetic (PBPK) Modeling in the IRIS Toxicological Review for Tetrachloroethylene (PDF)  (33  pp, 211.9 KB, about PDF)
• EPA’s Response to Major Interagency Comments on the Interagency Science Discussion Draft IRIS Toxicological Review of Tetrachloroethylene (PDF)  (9  pp, 88.9 KB, about PDF)
• 1. CDC ATSDR Perc IASD Comments (PDF)  (2  pp, 33.2 KB, about PDF)
• 2. CDC NIOSH Perc IASD Comments (PDF)  (4  pp, 41.0 KB, about PDF)
• 3. DOD Office of the Deputy Under Secretary of Defense (Installations & Environment) Perc IASD Comments - Part 1 (PDF)  (11  pp, 80.1 KB, about PDF)
• 4. DOD Office of the Deputy Under Secretary of Defense (Installations & Environment) Perc IASD Comments - Part 2 (PDF)  (2  pp, 18.6 KB, about PDF)
• 5. NASA Environmental Management Division (HQ) Perc IASD Comments (PDF)  (1  pp, 50.8 KB, about PDF)
• 6. NIEHS National Toxicology Program Perc IASD Comments (PDF)  (1  pp, 18.6 KB, about PDF)
• 7. OMB Office of Information and Regulatory Affairs Perc IASD Comments - Part 1 (PDF)  (4  pp, 39.1 KB, about PDF)
• 8. OMB Office of Information and Regulatory Affairs Perc IASD Comments - Part 2 (PDF)  (1  pp, 168.9 KB, about PDF)
• 9. SBA Office of Advocacy Perc IASD Comments - Part 1 (PDF)  (4  pp, 70.3 KB, about PDF)
• 10. SBA Office of Advocacy Perc IASD Comments - Part 2 (PDF)  (5  pp, 143.6 KB, about PDF)

Related Link(s)

• IRIS Toxicological Review of Tetrachloroethylene (Perchloroethylene) (External Review Draft)