Comptational comparison of asbestos fibers: Dosimetry model simulations to characterize variabilty and potency (Presentation poster)
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Inhaled asbestos fibers result in respiratory diseases such as asbestosis,
lung cancer and mesothelioma, but different asbestos fibers exhibit
different potency.
We applied a recently developed dosimetry model (Asgharian et al., Poster
# 104) that describes the aerodynamic behavior of inhaled fibers and
resultant deposition fractions (DF) in the human and rat respiratory tracts
to compare DF between environmental exposures of Libby amphibole (LA)
and amosite (AM).
Physiological parameters such as airway architecture, minute ventilation
rate (VE) and breathing mode (nasal or oral) can be varied in such models
to explore uncertainty inherent in risk assessments using average
exposure or default intake values.
We explore the impact of ventilation rate, age, and species differences on
various internal dose metrics to gain insights on potential differences in
potency for LA and AM.