IRIS Toxicological Review of Hexavalent Chromium Part 1: Experimental Animal Studies (Preliminary Assessment Materials, 2014)

Abstract

In April 2014, EPA released the draft literature searches and associated search strategies, evidence tables, and exposure response arrays for Cr(VI) to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested in comments on the following:

• Draft literature search strategies
• The approach for identifying studies
• The screening process for selecting pertinent studies
• The resulting list of pertinent studies
• Preliminary evidence tables
  • The process for selecting studies to include in evidence tables
  • The quality of the studies in the evidence tables

The literature search strategy, which describes the processes for identifying scientific literature, contains the studies that EPA considered and selected to include in the evidence tables. The preliminary evidence tables and exposure-response arrays present the key study data in a standardized format. The evidence tables summarize the available critical scientific literature. The exposure-response figures provide a graphical representation of the responses at different levels of exposure for each study in the evidence table.

Impact/Purpose

N/A

Citation

U.S. EPA. IRIS Toxicological Review of Hexavalent Chromium Part 1: Experimental Animal Studies (Preliminary Assessment Materials, 2014). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-14/094, 2014.

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

• Scoping information, preliminary literature search, associated strategy and evidence tables for Cr(VI) (PDF)  (112  pp, 2.0 MB, about PDF)
• Primary literature search references sorted by author (Cr(VI))
• Literature selection process for the Cr(VI) primary literature
• IRIS June 2014 Meeting & Presentations

Related Link(s)

• IRIS Toxicological Review of Hexavalent Chromium Part 2: Human, Toxicokinetic, and Mechanistic Studies (Preliminary Assessment Materials, 2014)