Updated Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials, 2019)
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Abstract
In March 2019, EPA released the Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials). As part of developing a draft IRIS assessment, EPA presents a methods document, referred to as the protocol, for conducting a chemical-specific systematic review of the available scientific literature. Protocols include strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.This protocol includes strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.
The IRIS Program posts assessment protocols and protocol updates publicly on a chemical’s HERO project page, the IRIS website, and in systematic review repositories such as Zenodo (https://zenodo.org/record/2654896#.XMsScOhKjcs).
Impact/Purpose
This document presents a draft assessment plan for hexavalent chromium that will be the subject of an SAB/Chemical Assessment Advisory Committee meeting in the spring of 2019 and that will define the scope and approach of the IRIS assessment of this chemical.Status
The IRIS Program will use the methods for conducting the systematic review as described in the protocol to develop the draft assessment.Citation
U.S. EPA. Updated Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials, 2019). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-18/155, 2019.History/Chronology
Date | Description |
---|---|
01- Apr 2014 | EPA released preliminary meeting materials for chromium (VI), part 1, in preparation for the June 2014 Bimonthly Public Science Meeting. |
02- Jun 2014 | EPA hosted a public science meeting to discuss preliminary meeting materials for chromium (VI), part 1. |
03- Aug 2014 | EPA released preliminary meeting materials for chromium (VI), part 2, in preparation for the October 2014 Bimonthly Public Science Meeting. |
04- Oct 2014 | EPA hosted a public science meeting to discuss preliminary meeting materials for chromium (VI), part 2. |
05- Mar 2019 | EPA released the Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials). [Federal Register Notice Mar 15, 2019] |
06- Apr 2019 | EPA announced that they will host a public science meeting on April 24, 2019 (by webinar) to discuss the draft document. |
07- Oct 2022 | EPA released an update to the IRIS hexavlent chromium protocol. |
08- Aug 2024 | EPA released the final IRIS hexavalent chromium protocol. |
Download(s)
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials) (PDF) (41 pp, 1.8 MB, about PDF)
- An Update to the Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Oct 2022)
- Final Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (August 2024) (PDF) (159 pp, 2.0 MB, about PDF)
- IRIS Public Science Meeting (April 2019) -- Hexavalent Chromium