Development and Harmonization of Organotypic/Co-Culture Models and Assays to Improve Throughput and In Vivo Relevance in Inhaled Chemical Testing
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- Bronchial epithelial cell models provide valuable information but are not representative of other aspects of the structure and function of a complex tissue,
- Fit-for-purpose multi-cellular models are necessary for accurate, reliable, and defensible inhalation toxicity testing and computational model.
- Human data from environmental inhaled materials is invaluable in lung model development and validation.