Fetal and neonatal effects of in utero exposure to perfluoroalkyl ether acids in the Sprague-Dawley rat

This is an invited seminar presentation at Duke University within the Integrated Toxicology & Environmental Health Program. No abstract.

Impact/Purpose

PFAS toxicity is an area of high priority research for multiple state and international health based agencies. The specific mechanisms of action and critical key events involved in the adverse developmental effects of gestational exposure are still not well described. Further, a range of emerging perfluoroalkyl ether acids have been identified in surface water, drinking water, and human serum that have little or not available toxicity data to inform risk assessments. Our group has expertise in the effects of in utero exposure to environmental chemicals and subsequent effects on the fetus and neonate and have been performing both individual chemical and mixture-based in vivo studies to elucidate target organs, molecular mechanisms, and critical key events for development of multiple Adverse Outcome Pathways associated with PFAS-relevant MIEs.

Citation

Conley, J. Fetal and neonatal effects of in utero exposure to perfluoroalkyl ether acids in the Sprague-Dawley rat. Duke University Integrated Toxicology & Environmental Health Program Seminar, Durham, NC, December 13, 2019.