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NAFTA Developmental Neurotoxicity Guidance Document: Tests of Learning and Memory

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  • Overview
 This presentation covers the diversity of behavioral tests that are available with focus on those most routinely adopted by companies conducting Developmental Neurotoxicity Guideline studies (DNT). Overview of appropriate procedures in conduct of these various tasks, the best practices for data collection and reporting, and statistical analyses.

Impact/Purpose

Provide educational seminar on the assessment and interpretation of in vivo Developmental Neurotoxicity Guideline (DNT) studies to  European Food Safety Assessment (EFSA) staff. This is focussed on on the objectives of the DNT Guideline, data types collected, and the interpretation data on tests of learning and memory based on the 2016 NAFTA document entitled “Developmental Neurotoxicity Study (DNT) Guidance Document”.  The goal is to inform and help staff identify both strengths and  inadequacies in submitted data and determine what additional data they may require to make consistent and scientifically sound decisions.

Citation

Gilbert, Mary E. NAFTA Developmental Neurotoxicity Guidance Document: Tests of Learning and Memory. European Food Safety Association (EFSA)-Virtual, Research Triangle Park, Virtual, ITALY, April 26, 2021.
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Last updated on April 30, 2021
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