Male reproductive toxicity in epidemiology studies of phthalates: a case study application of systematic review approaches-Poster
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Systematic review plays an important role in enhancing scientific rigor and transparency. The Human Health Risk Assessment Program is advancing the application of systematic review across their portfolio of assessment products. Case studies are presented to highlight the advancements in systematic review throughout assessment development, and this example shows the application to epidemiology evidence. Phthalates have anti-androgenic activity in rodents resulting in reduced circulating testosterone and male reproductive tract abnormalities. Several epidemiologic studies have examined this association in humans. The Integrated Risk Information System (IRIS) performed a systematic review of all male reproductive effects of phthalate exposure, implementing new approaches intended for use in all future IRIS assessments, following recommendations in the 2014 NAS review of the IRIS program. This presentation examines the associations between anogenital distance (AGD) in humans and two phthalates, di(2-ethylhexl phthalate (DEHP) and diisobutyl phthalate (DIBP), as a case study of the IRIS systematic review process.