IRIS Toxicological Review of Formaldehyde-Inhalation (Interagency Science Consultation Draft, 2021)
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Abstract
In April 2022, EPA publicly released the draft formaldehyde assessment for review and comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House Offices before public release. Through the IRIS process, all written comments on IRIS assessments submitted by other federal agencies and White House Offices will be made publicly available. Accordingly, interagency comments and the interagency science consultation draft of the IRIS Toxicological Review of Formaldehyde-Inhalation are posted on this site.Formaldehyde is present in a variety of products including plywood adhesives, abrasive materials, insulation, pesticides, and embalming fluids. Major sources of anthropogenic emissions include household furnishings and building materials, motor vehicle exhaust, manufacturing plants that produce or use formaldehyde or substances that contain it (e.g., glues), and tobacco smoke.
Impact/Purpose
The IRIS Toxicological Review of Formaldehyde-Inhalation provides scientific support and rationale for the hazard and dose-response assessment pertaining to inhalation exposure to formaldehyde.Citation
U.S. EPA. IRIS Toxicological Review of Formaldehyde-Inhalation (Interagency Science Consultation Draft, 2021). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-21/286, 2021.History/Chronology
| Date | Description |
|---|---|
| 06- May 2011 | NAS's Board on Environmental Studies and Toxicology (BEST) releases the NAS Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde (Final Report). |
| 07- Apr 2014 | EPA convened a state-of-the-science workshop on formaldehyde on April 30 and May 1, 2014 in Arlington, VA. This workshop focused on 3 themes, see the web site for specific details. |
| 08- Jun 2018 | The IRIS Assessment of Formaldehyde-Inhalation Agency Review draft (completed in 2017) is formally suspended. |
| 10- Mar 2021 | EPA updates the list of priority assessments developed by IRIS. EPA unsuspends the IRIS Toxicological Review of Formaldehyde-Inhalation. |
| 11- Dec 2021 | EPA initiated an interagency science consultation on the draft Toxicological Review of Formaldehyde-Inhalation. |
| 12- Apr 2022 | EPA released the draft Toxicological Review of Formaldehyde-Inhalation for public comment and subsequent external peer review by the National Academies of Sciences, Engineering, and Medicine. |
Download(s)
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- IRIS Toxicological Review of Formaldehyde-Inhalation (Interagency Science Consultation Review Draft) (PDF) (780 pp, 14.1 MB, about PDF)
- IRIS Toxicological Review of Formaldehyde-Inhalation Supplemental Information (Interagency Science Consultation Review Draft) (PDF) (1063 pp, 15.1 MB, about PDF)
- Assessment Overview for the Toxicological Review of Formaldehyde-Inhalation (Dec 2021) (PDF) (191 pp, 3.8 MB, about PDF)
- Draft Charge Questions for Reviewers (Dec 2021) (PDF) (8 pp, 215.8 KB, about PDF)
- 1. ATSDR Comments on the IASC Draft of Formaldehyde-Inhalation (PDF) (30 pp, 643.6 KB, about PDF)
- 2. DoD Comments on the IASC Draft of Formaldehyde-Inhalation (PDF) (2 pp, 137.7 KB, about PDF)
- 3. EOP Comments on the IASC Draft of Formaldehyde-Inhalation (PDF) (2 pp, 177.7 KB, about PDF)
- 4. NIEHS Comments on the IASC Draft of Formaldehyde-Inhalation (PDF) (15 pp, 205.1 KB, about PDF)
- 5. NIOSH Comments on the IASC Draft of Formaldehyde-Inhalation (PDF) (2 pp, 148.4 KB, about PDF)
- 6. SBA Comments on the IASC Draft of Formaldehyde-Inhalation (PDF) (6 pp, 232.4 KB, about PDF)