Developmental toxicity of Nafion byproduct 2 (NBP2) in the Sprague-Dawley rat with comparisons to hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) and perfluorooctane sulfonate (PFOS)
This sub-product will describe data generated from short-term fetal studies and a longer-term postnatal study in Sprague-Dawley rats on the key events and adverse outcomes of oral gestational exposure to the emerging PFAS, Nafion byproduct 2. Nafion is a perfluoroalkyl ether sulfonic acid that was recently detected in the serum of 99% of a study population in eastern NC, however there are no peer-reviewed published toxicity studies for this compound. Studies include gene expression, clinical chemistry, apical endpoints, and measures of chemical concentrations in serum and liver of maternal and F1 animals.