Application of the Generalized Concentration Addition Model to Predict In Vitro Responses of Tertiary Mixtures of Glucocorticoid Ligands@
On this page:
Prescription and endogenous glucocorticoid ligands are frequently reported in environmental surface water, sewage treatment plant influent, wastewater effluent, hospital effluent, and industrial effluent due to the inability of wastewater treatment plants to effectively eliminate these bioactive compounds, leading to potentially harmful exposures. As a result, it is increasingly imperative to predict adverse outcomes of exposure and expedite water quality testing. An emerging focus of toxicological research aims to improve these methods by developing computational models to predict joint-responses of chemical mixtures. In this study, we expand the application of the generalized concentration addition model and demonstrate its ability to accurately predict the summed response produced by tertiary mixtures containing full and partial agonists. This broadened application could save time, resources, and costs associated with experimental studies to determine joint-responses of more complex mixtures accurately representing environmental concentrations.