In vitro activity of a panel of per- and polyfluoroalkyl substances (PFAS), fatty acids, and pharmaceuticals in peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, and estrogen receptor
This sub-product will describe data generated from in vitro receptor binding assays for peroxisome proliferator activated receptor alpha, beta/delta, and gamma for a range of PFAS, fatty acids, and clofibric acid. Addtionally, these compounds were tested for in vitro estrogen, androgen, and glucocorticoid receptor transcriptional activaition. The manuscript will report measures of chemical efficacy and potency in each of the assays and will provide molecular initiating event information for AOP development.