Impacts of Inter-Individual Variability on Differentiated Primary Cell-Based In Vitro Models for Inhaled Chemical Safety Evaluation

•Building confidence in the ability of in vitro systems and data to recapitulate/predict in vivo responses is complex issue that is critical for acceptance.   •Part 1: How do inter-individual variability and repeated exposures affect exposure outcomes?   •Part 2: How are in vitro exposure outcomes and subsequent extrapolations affected by test agent dose delivery?     •Part 3: Do commonly used in vitro systems represent the roles of different cell types that exist in vivo as targets and mediators of inhaled chemical exposures?   Work will be presented to describe observations regarding to the presence and characterization of inter-individual varaibility in primary cell-based in vitro models of the human respiratory tract. NOTE: there is no abstract for this presentation. 

Impact/Purpose

Work will be presented to describe observations regarding to the presence and characterization of inter-individual varaibility in primary cell-based in vitro models of the human respiratory tract.

Citation

McCullough, S. Impacts of Inter-Individual Variability on Differentiated Primary Cell-Based In Vitro Models for Inhaled Chemical Safety Evaluation. National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) Population Variability Webinar 3, Virtual, NC, October 07, 2022.