Cumulative maternal and neonatal effects of combined exposure to a mixture of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) during pregnancy in the Sprague-Dawley rat
This sub-product will describe data generated from postnatal studies in Sprague-Dawley rats on the key events and adverse outcomes of oral gestational exposure to a mixture of PFOA and PFOS. Each of these compounds has been shown to individually produce numerous maternal and offspring effects following in utero exposure. This study investigates a theory of dose additivity in which the chemicals were predicted to produce cumulative effects.