Not a One-Size-Fits-All Solution: ?EPA’s Flexible PBPK Template Software Exactly Replicates Many Models
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[This abstract was written by the organizer and also describes a presentation by Cecilia Tan, which she is developing and clearing separately.]
The development of physiologically-based pharmacokinetic (PBPK) models have grown steadily since their emergence. However, the lack of a standardized template for PBPK model coding and analysis reporting has considerably hindered the sharing, reusing, and reviewing of developed models and the acceptance of PBPK models as risk assessment tools by regulatory agencies. In this webinar, two speakers, Drs. Cecilia Tan and Paul Schlosser from USEPA, will share their recent efforts in the front of standardization of PBPK practice for environmental chemicals. Dr. Tan will present a harmonized reporting template that can be adopted and customized by public health agencies receiving PBPK model submission. The template can also serve as general guidance for submitting PBPK-related studies for publication in journals or other modeling sharing purposes. Dr. Schlosser will present a PBPK model coding template in the freely available R language by using a case study on per- and polyfluoroalkyl Substances. The template, once established and thoroughly reviewed for a class of compounds, will insulate subsequent reviewers from repeating the tedious process and allow them to only focus on the parameter inputs and exposure scenarios applied, thus making the review process more efficient and less error-prone. In summary, standardization of model coding and reporting will facilitate PBPK modeling as a risk assessment tool.