PFAS PK Challenges
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Per- and Polyfluoroalkyl substances (PFAS) are a class of persistant chemicals to which most individuals are commonly exposed. Due to the ubiquity of exposure and links to toxic effects in animal and epidemiological studies, the need for chemical risk assessment of these chemicals is apparent. One challenge to risk assessors is the difficulty in applying dosimetric methods to PFAS due to thier high affinity interactions with transporters and binding proteins. These interactions can result in non-linear pharmacokinetics and in kinetics that differ by sex and age. This presentation briefly summarizes some of the challenges in applying dosimetric methods to PFAS and some of the possible solutions and ongoing work to address these issues.