Health Effects Determinations of Current and Emerging Sources of Air Pollution
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Air pollution inhalation continues to exact a substantial public health burden, driven largely by adverse cardiovascular outcomes. The precise reasons accounting for this are unclear, but may relate to new and emerging sources of air pollution, the increasing prevalence of intrinsic and extrinsic factors that elevate risk, and lingering uncertainty regarding the identity of the chemical constituents and biological mechanisms that mediate such responses. This seminar will present various approaches used to assess the health and biological effects of air pollution, particularly adverse cardiovascular and pulmonary outcomes. The relative toxicity, mechanisms, and emissions chemistry of key current and emerging sources of air pollution including traffic, wildland fires, and house fires will also be discussed. Finally, the seminar will conclude with a discussion of how toxicological findings are combined with human epidemiological and clinical data to inform integrated scientific assessments for key air pollutants.