Protocol for the Vanadium and Compounds (Inhalation) IRIS Assessment (Preliminary Assessment Materials)

Abstract

In August 2023, EPA released the systematic review Protocol for the Vanadium and Compounds (Inhalation) IRIS Assessment (Preliminary Assessment Materials). As part of developing a draft IRIS assessment, EPA presents a protocol that describes the methodology for how the assessment will be conducted, including systematic review and dose-response. These could include strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.
Vanadium is a transition metal that occurs naturally in Earth’s crust. Fossil fuel combustion is thought to be the major anthropogenic source of vanadium to the atmosphere. The use of heavy oils and bitumen from tar sands and the use of vanadium in industrial applications (e.g., steel production, vanadium redox-flow batteries, and catalytic converters) can contribute to the release of vanadium into the environment.

Impact/Purpose

This document presents a draft assessment plan for vanadium and compounds (inhalation exposure) that will be the subject of a peer review meeting in 23/24 and that will define the scope and approach of the IRIS assessment for vanadium and compounds (inhalation exposure).

Status

The IRIS Program will use the methods for conducting the systematic review as described in the protocol to develop the draft assessment.

Citation

U.S. EPA. Protocol for the Vanadium and Compounds (Inhalation) IRIS Assessment (Preliminary Assessment Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-23/167, 2023.

Date	Description
01- May 2021	EPA released the IRIS Assessment Plan for inhalation exposure to vanadium and compounds for public comment and review. [Federal Register Notice May 28, 2021]
02- Jun 2021	EPA announced an extension of the public comment period until July 13, 2021. [Federal Register Notice Jun 25, 2021]
03- Aug 2023	EPA released the Systematic Review Protocol for the Vanadium and Compounds (Inhalation) IRIS Assessment (Preliminary Assessment Materials) for public comment and review. [Federal Register Notice Aug 28, 2023 ]

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

• Protocol for the Vanadium and Compounds (Inhalation) IRIS Assessment (Preliminary Assessment Materials) (PDF)  (136  pp, 1.9 MB, about PDF)

Related Link(s)

• Health Effects Assessment for Vanadium and Compounds
• IRIS Toxicological Review of Vanadium Pentoxide (External Review Draft, 2012)
• Systematic Review Protocol for the Vanadium and Compounds (Oral Exposure) IRIS Assessment (Preliminary Assessment Materials)
• IRIS Assessment Plan for Inhalation Exposure to Vanadium and Compounds (Scoping and Problem Formulation Materials)

HERO Project

• Literature Search References Sorted By Author (Vanadium Inhalation)

Docket

Comments on the assessment may be submitted and reviewed using the Docket ID EPA-HQ-ORD-2020-0182