Reporting Requirements and Analyses Needed to Establish Confidence in NAMs for Nano-Safety Assessment
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Presentation focuses on current challenges and strategies for evidence integration in risk assessment, including comprehensive source to outcome characterization and using AEP and AOP frameworks to create a conceptual mechanistic scaffold by which to evaluate and integrate NAMs into assessments. Emphasis is placed on exposure alignment across experimental platforms and the critical role of dosimetry modeling in assessment work flows to link exposure with various key events in an AOP. Reporting standards are presented as a roadmap for advancing characterization of exposure and responses of emerging assays in context with extant data via integrated approaches to testing and assessment (IATA).