Expanded Systematic Evidence Map for Hundreds of Per- and Polyfluoroalkyl Substances (PFAS) and Comprehensive PFAS Human Health Dashboard

Systematic evidence mapping for PFAS structures to characterize human health literature for 430 prioritized PFAS. Systematic evidence maps are pre-decisional analyses that use systematic review methods to compile and summarize evidence, but do not include hazard assessment or toxicity value conclusions. 

Impact/Purpose

Systematic Evidence Map (SEM) methods were used to survey and summarize available epidemiological and mammalian animal bioassay evidence that could inform human hazard identification for an expanded set of ~345 PFAS identified by US EPA's CCTE for in vitro toxicity and toxicokinetic assay testing.

Citation

Shirke, A., E. Radke-Farabaugh, C. Lin, R. Blain, N. Vetter, C. lemeris, p. hartman, H. Hubbard, M. Angrish, X. Arzuaga Andino, J. Congleton, J. Davis, L. Dishaw, R. Jones, R. Judson, J. Kaiser, A. Kraft, L. Lizarraga, Pamela Noyes, G. Patlewicz, M. Taylor, A. Williams, Kristina Chialton, AND L. Carlson. Expanded Systematic Evidence Map for Hundreds of Per- and Polyfluoroalkyl Substances (PFAS) and Comprehensive PFAS Human Health Dashboard. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 132(2):CID: 026001, (2024). [DOI: 10.1289/EHP13423]

• https://ehp.niehs.nih.gov/doi/10.1289/EHP13423

DOI: Expanded Systematic Evidence Map for Hundreds of Per- and Polyfluoroalkyl Substances (PFAS) and Comprehensive PFAS Human Health Dashboard