Provisional Peer-Reviewed Toxicity Values for 1-Phenyl-1-(4-Methylphenyl)ethane (Pte) (Casrn 3717-68-8)

1-Phenyl-1-(4-methylphenyl)ethane (PTE), CASRN 3717-68-8, is a discrete organic chemical; it is a hydrocarbon containing both aromatic and aliphatic carbons (see Figure 1). PTE is not listed with the EPA Substance Registry Services (U.S. EPA, 2022c). It is not listed on TSCA’s public inventory or the European Chemicals (EC) inventory (ECHA, 2022; U.S. EPA, 2022d). Synonyms of 1-phenyl-1-(4-methylphenyl)ethane appearing in these databases and in other sources include 1-methyl-4-(1-phenylethyl)benzene, 1-phenyl-1-(p-tolyl)-ethane, 4?(1?phenylethyl)toluene, and methylphenyl-p-tolylmethan. There are no data available on the production of PTE in the United States or commercial uses reported for PTE (NLM, 2022b; U.S. EPA, 2022d). This is a no-value PPRTV.

Impact/Purpose

A Provisional Peer-Reviewed Toxicity Value (PPRTV) is defined as a toxicity value derived for use in the Superfund program. PPRTVs are derived after a review of the relevant scientific literature using established U.S. Environmental Protection Agency (U.S. EPA) guidance on human health toxicity value derivations. The purpose of this document is to provide support for the hazard and dose?response assessment pertaining to chronic and subchronic exposures to substances of concern, to present the major conclusions reached in the hazard identification and derivation of the PPRTVs, and to characterize the overall confidence in these conclusions and toxicity values. It is not intended to be a comprehensive treatise on the chemical or toxicological nature of this substance.

Citation

Choi, K. Provisional Peer-Reviewed Toxicity Values for 1-Phenyl-1-(4-Methylphenyl)ethane (Pte) (Casrn 3717-68-8). U.S. Environmental Protection Agency, Washington, DC, EPA/690/R-24/002F, 2024.

Date	Description
01- Jan 2024	EPA published the final report and values on the PPRTV website.
02- Sep 2024	EPA finalized and delivered the assessment to the Superfund Program.

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