Provisional Peer-Reviewed Toxicity Values for P-Isopropyltoluene (Casrn 99-87-6)
This PPRTV was requested by the Office of Land and Emergency Management (OLEM). PPRTV assessments support the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) and Resource Conservation and Recovery Act (RCRA). These assessments support EPA's Superfund program to: manage the cleanup of the nation's worst hazardous waste sites, transform wastelands into economic and productive uses again, and respond to local, state, and nationally significant environmental emergencies. The PPRTV assessments provide support for the hazard and dose-response assessment pertaining to chronic and subchronic exposures to substances of concern, present the major conclusions reached in the hazard identification and derivation of the provisional toxicity values, and characterize the overall confidence in these conclusions and toxicity values. Read-across approaches are applied to the evaluation of data poor chemicals where little to no data is available for the chemical of concern.
Impact/Purpose
A Provisional Peer-Reviewed Toxicity Value (PPRTV) is defined as a toxicity value derived for use in the Superfund program. PPRTVs are derived after a review of the relevant scientific literature using established U.S. Environmental Protection Agency (U.S. EPA) guidance on human health toxicity value derivations. The purpose of this document is to provide support for the hazard and dose response assessment pertaining to chronic and subchronic exposures to substances of concern, to present the major conclusions reached in the hazard identification and derivation of the PPRTVs, and to characterize the overall confidence in these conclusions and toxicity values. It is not intended to be a comprehensive treatise on the chemical or toxicological nature of this substance.Citation
Lizarraga, L. Provisional Peer-Reviewed Toxicity Values for P-Isopropyltoluene (Casrn 99-87-6). U.S. Environmental Protection Agency, Washington, DC, EPA/690/R-24/003F, 2024.Download(s)
- Final p-Isopropyltoluene PPRTV (PDF) (128 pp, 2.8 MB, about PDF)
- https://www.epa.gov/pprtv