RIVM PFAS Mixtures Risk Assessment Workshop - PFAS mixtures research and risk assessment
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Due to the pervasive detection of multiple PFAS in human and environmental matrices, many health-based agencies are employing or pursuing cumulative assessment and regulatory approaches. However, the literature is lacking mammalian in vivo studies that test additivity by comparing observed mixture responses to mixture model predictions. We have conducted three different PFAS mixture studies investigating maternal and neonatal effects from maternal exposure during pregnancy in a rat model. Experimental data were compared to predictions using established mixtures toxicology approaches and effects were well predicted using dose addition methods. One of the mixture studies discussed here (PFOA+PFOS mixture) was the result of a request from the Office of Water for technical support of cumulative effects of exposure to multiple PFAS.