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Workshop Report: Development of an Evidence-Based Risk Assessment Framework

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  Assessment of potential human health risks associated with environmental and other agents requires careful evaluation of all available and relevant evidence for the agent of interest, including both data-rich and data-poor agents. With the advent of new approach methodologies in toxicological risk assessment, guidance on integrating evidence from multiple evidence streams is needed to ensure that all available data is given due consideration in both qualitative and quantitative risk assessment. The present report summarizes the discussions among academic, government, and private sector participants from North America and Europe in an international workshop convened to explore the development of an evidence-based risk assessment framework, taking into account all available evidence in an appropriate manner in order to arrive at the best possible characterization of potential human health risks and associated uncertainty. Although consensus among workshop participants was not a specific goal, there was general agreement on the key considerations involved in evidence-based risk assessment incorporating 21st century science into human health risk assessment. These considerations have been embodied into an overarching prototype framework for evidence integration that will be explored in more depth in a follow-up meeting.

Impact/Purpose

Summary of discussions and comparisons of evidence synthesis and integration methods across data-rich and data-poor assessment needs. The workshop involved a number of international experts across government, academia, and industry.

Citation

Kraft, A. Workshop Report: Development of an Evidence-Based Risk Assessment Framework. Society ALTEX Edition, Kuesnacht, SWITZERLAND, 9(4):667-693, (2022). [DOI: 10.14573/altex.2004041]

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  • https://www.altex.org/index.php/altex/article/view/1764
DOI: Workshop Report: Development of an Evidence-Based Risk Assessment Framework
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Last updated on January 28, 2025
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